Chemical Constituents of Aglaia odorata Leaves and Their Anti-inflammatory Effects

Efdi, Mai and Pardede, Antoni and kakumu, Akinori and Hara, Hirokazu and Syafrizayanti, Syafrizayanti and Ariesanty, Desi and Ninomiya, Masayuki and Koketsu, Mamoru (2017) Chemical Constituents of Aglaia odorata Leaves and Their Anti-inflammatory Effects. Natural Product Communications, 12 (11). pp. 1717-1720. ISSN ISSN: 1934-578X dan Online ISSN: 1555-9475

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Aglaia odorata Lour. is a traditional herbal medicine belonging to the Meliaceae family. The aim of this study was to identify useful compounds for human health from A. odorata. Our phytochemical investigation resulted in the isolation of four constituents hesperetin-7,3'-O-dimethylether, 5α-dammar-20-ene- 3,24,25-triol, odorine, and odorinol. All compounds suppressed LPS-induced TNF- expression in rat immortalized microglia HAPI cells; especially, hesperetin-7,3'-O-dimethylether showed most potent inhibitory effect. In addition, molecular docking analysis demonstrated that hesperetin-7,3'-Odimethylether could be accommodated within hot spots of TNF- dimeric protein.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Undergraduate Theses > Faculty of Teacher Training and Education > Department of Chemistry Education
Depositing User: Unnamed user with email
Date Deposited: 27 Sep 2019 06:53
Last Modified: 27 Sep 2019 06:53

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